Sébastien Clercq, Adil Mouahid, Pèpe Gérard, Elisabeth Badens. Investigation of crystallization mechanisms for polymorphic and habit control from the Supercritical AntiSolvent process. Journal of Supercritical Fluids, Elsevier, 2018, 141, pp.29-38. ⟨10.1016/j.supflu.2017.11.025⟩. ⟨hal-02113962⟩ Plus de détails...
In this work, the Supercritical AntiSolvent (SAS) process has been used to generate micronized crystals of Sulfathiazole (STZ) from different organic solutions, namely acetone, acetonitrile, tetrahydrofuran and acetic acid. The flow rates of CO2 (2–21 g min−1) and of the organic solution (0.19–6 mL min−1), as well as STZ concentration in the organic solution (20–70% under the saturation), have been varied to identify the conditions leading to powders exhibiting only one polymorphic form. Pressure (10 MPa) and temperature (313 K) have been kept constant. In this paper, thermodynamic and hydrodynamic aspects are discussed so as to rationalize the obtained crystal characteristics and provide a new way to control the SAS process applied to drug pre-formulation. The influence of the organic solvent nature on both the polymorphic form and the habit of generated crystals, has been particularly discussed.
Sébastien Clercq, Adil Mouahid, Pèpe Gérard, Elisabeth Badens. Investigation of crystallization mechanisms for polymorphic and habit control from the Supercritical AntiSolvent process. Journal of Supercritical Fluids, Elsevier, 2018, 141, pp.29-38. ⟨10.1016/j.supflu.2017.11.025⟩. ⟨hal-02113962⟩
Adil Mouahid, Halima Bouanga, Christelle Crampon, Elisabeth Badens. Supercritical CO2 extraction of oil from Jatropha curcas: An experimental and modelling study. Journal of Supercritical Fluids, Elsevier, 2018, 141, pp.2-11. ⟨10.1016/j.supflu.2017.11.014⟩. ⟨hal-02114700⟩ Plus de détails...
Experimental and modelling investigations of supercritical CO 2 extraction of oil from Jatropha curcas were conducted at a pressure range of 20-40 MPa and a temperature range of 313-333 K at a CO 2 flow rate of 0.4 kg/ h. The extraction yield was estimated to be about 0.6 kg oil /kg biomass for all experiments. The model of broken and intact cells published by Sovová was applied. It was found that the extraction of type B was the most suited extraction type to apply as the experimental extraction curves exhibit three parts. Whatever the pressure and the temperature applied, the asymptotic yield at infinite time was found to be the same. At 20 MPa, increasing the temperature from 313 to 323 K enhances the extraction kinetics. A retrograde solubility zone was found at 30 and 40 MPa. The Jatropha curcas oil solubility in SC-CO 2 was determined and the data were modelled with the Chrastil equation.
Adil Mouahid, Halima Bouanga, Christelle Crampon, Elisabeth Badens. Supercritical CO2 extraction of oil from Jatropha curcas: An experimental and modelling study. Journal of Supercritical Fluids, Elsevier, 2018, 141, pp.2-11. ⟨10.1016/j.supflu.2017.11.014⟩. ⟨hal-02114700⟩
Elisabeth Badens, Yasmine Masmoudi, Adil Mouahid, Christelle Crampon. Current situation and perspectives in drug formulation by using supercritical fluid technology. Journal of Supercritical Fluids, Elsevier, 2018, 134, pp.274-283. ⟨10.1016/j.supflu.2017.12.038⟩. ⟨hal-02111546⟩ Plus de détails...
Supercritical fluid (SCF) technology has been applied to drug product development over the last thirty years and drug particle generation using SCFs appears to be an efficient way to carry out drug formulation which will form end-products meeting targeted specifications. This article presents an overview of drug particle design using SCFs from a rather different perspective than usual, more focused on chemical and process engineering aspects. The main types of existing processes are described in a concise way and a focus is put on how to choose the right operating conditions considering both thermodynamic and hydrodynamic aspects. It is shown that the operating conditions and parameters can be easily optimized so as to facilitate the further process scale-up. Furthermore, the new trends in particle generation using SCFs are introduced, related either to new types of drug medicines that are treated or new ways of process implementation methods.
Elisabeth Badens, Yasmine Masmoudi, Adil Mouahid, Christelle Crampon. Current situation and perspectives in drug formulation by using supercritical fluid technology. Journal of Supercritical Fluids, Elsevier, 2018, 134, pp.274-283. ⟨10.1016/j.supflu.2017.12.038⟩. ⟨hal-02111546⟩
Adil Mouahid, Cyril Dufour, Elisabeth Badens. Supercritical CO 2 extraction from endemic Corsican plants; comparison of oil composition and extraction yield with hydrodistillation method. Journal of CO2 Utilization, Elsevier, 2017, 20, pp.263 - 273. ⟨10.1016/j.jcou.2017.06.003⟩. ⟨hal-01596432⟩ Plus de détails...
Generally speaking, essential oils (EOs) and components of interest are extracted from plants using hydrodistillation (HD), steam distillation or organic solvent methods The Supercritical CO2 (SC-CO2) extraction technique is a good alternative to the three previously mentioned methods as it is able to be applied at temperatures close to ambient and shows no toxicity to humans or the environment. The aim of this study is to investigate the ability of supercritical CO2 extraction to extract bioactive components from four Corsican endemic plants: Rosmarinus officinalis, Juniperus communis ssp nana, Helichrysum italicum and Pistacia lentiscus. After the extracts were analyzed by gas chromatography, it would appear that SC-CO2 is the most adapted process for the extraction of such components of interest as verbenone, germacrene D, bornyl acetate, ferruginol, transcaryophyllene, elemol,gamma-cadinene, geraniol or beta-eudesmol in higher quantity. The SC-CO2 extraction curves were obtained using two models published by Sovova. These models give access to complementary information and help to estimate the values of some important data such as the possible maximal extraction yield for Helichrysum italicum and the end of the extraction period.
Adil Mouahid, Cyril Dufour, Elisabeth Badens. Supercritical CO 2 extraction from endemic Corsican plants; comparison of oil composition and extraction yield with hydrodistillation method. Journal of CO2 Utilization, Elsevier, 2017, 20, pp.263 - 273. ⟨10.1016/j.jcou.2017.06.003⟩. ⟨hal-01596432⟩
Adil Mouahid, Christelle Crampon, Sid-Ali Amine Toudji, Elisabeth Badens. Effects of high water content and drying pre-treatment on supercritical CO2 extraction from Dunaliella salina microalgae: Experiments and modelling. Journal of Supercritical Fluids, Elsevier, 2016, 116, pp.271-280. ⟨10.1016/j.supflu.2016.06.007⟩. ⟨hal-01461796⟩ Plus de détails...
This study investigates the effects due to the water content and to the drying pre-treatment on the extraction kinetics of solutes extracted from Dunaliella sauna microalgae by supercritical CO2. The extraction experiments were conducted at pressure range from 20 up to 40 MPa at a temperature of 333 K on crushed samples with water content varying from 5.5 up to 23 wt%. Three drying pre-treatments were applied: air flow drying at 318 K, air flow drying followed by additional microwave treatment and freeze-drying. A water content up to 23 wt% helps to extract a higher content of carotenoids (mainly beta-carotene) and does not restrict the extraction process. Sovova's mathematical model was applied and the parameters were adapted for the description of the extraction curves from samples containing high water content with a deviation between experimental and calculated values comprised between 1.1% and 4.3%. (C) 2016 Elsevier B.V. All rights reserved.
Adil Mouahid, Christelle Crampon, Sid-Ali Amine Toudji, Elisabeth Badens. Effects of high water content and drying pre-treatment on supercritical CO2 extraction from Dunaliella salina microalgae: Experiments and modelling. Journal of Supercritical Fluids, Elsevier, 2016, 116, pp.271-280. ⟨10.1016/j.supflu.2016.06.007⟩. ⟨hal-01461796⟩
Gregory Cano, Adil Mouahid, Emilie Carretier, Pascal Guasp, Didier Moulin, et al.. Computational fluid dynamics simulations of membrane filtration process adapted for water treatment of aerated sewage lagoons. Water Science and Technology, IWA Publishing, 2015, 71 (2), pp.197 - 202. ⟨10.2166/wst.2014.476⟩. ⟨hal-01916461⟩ Plus de détails...
Gregory Cano, Adil Mouahid, Emilie Carretier, Pascal Guasp, Didier Moulin, et al.. Computational fluid dynamics simulations of membrane filtration process adapted for water treatment of aerated sewage lagoons. Water Science and Technology, IWA Publishing, 2015, 71 (2), pp.197 - 202. ⟨10.2166/wst.2014.476⟩. ⟨hal-01916461⟩
Grégory Cano, Adil Mouahid, Emilie Carretier, Pascal Guasp, Didier Dhaler, et al.. Computational fluid dynamics simulations of membrane filtration process adapted for water treatment of aerated sewage lagoons. Water Science and Technology, IWA Publishing, 2015, 71 (2), pp.197-202. ⟨10.2166/wst.2014.476⟩. ⟨hal-01143831⟩ Plus de détails...
The aim of this study is to apply the membrane bioreactor technology in an oxidation ditch in submerged conditions. This new wastewater filtration process will benefit rural areas (<5,000 population equivalent) subject to chronic water shortages by reusing this water for irrigation of green areas. For this purpose, the membranes developed without support are immersed in an aeration well and work in suction mode. The development of the membrane without support and more precisely the performance of spacers are approached by computational fluid dynamics in order to provide the best compromise between pressure drop/flow velocity and permeate flux. The numerical results on the layout and the membrane modules' geometry in the aeration well indicate that the optimal configuration is to install the membranes horizontally on three levels. Membranes should be connected to each other to a manifold providing a total membrane area of 18 m(2). Loss rate compared to the theoretical throughput is relatively low (less than 3%). Preliminary data obtained by modeling the lagoon provide access to its hydrodynamics, revealing that recirculation zones can be optimized by making changes in the operating conditions. The experimental validation of these results and taking into account the aeration in the numerical models are underway.
Grégory Cano, Adil Mouahid, Emilie Carretier, Pascal Guasp, Didier Dhaler, et al.. Computational fluid dynamics simulations of membrane filtration process adapted for water treatment of aerated sewage lagoons. Water Science and Technology, IWA Publishing, 2015, 71 (2), pp.197-202. ⟨10.2166/wst.2014.476⟩. ⟨hal-01143831⟩
Christelle Crampon, Adil Mouahid, Sid-Ali Amine Toudji, Olivier Lépine, Elisabeth Badens. Influence of pretreatment on supercritical CO2 extraction from Nannochloropsis oculata. Journal of Supercritical Fluids, Elsevier, 2013, 79, pp.337-344. ⟨10.1016/j.supflu.2012.12.022⟩. ⟨hal-00993082⟩ Plus de détails...
This work demonstrates that supercritical carbon dioxide extraction is efficient for the complete recovery of neutral lipids from microalgae with a water content up to 20 wt%, allowing thus a further full characterization of this oil. This is a first useful step in the framework of lipid production from microalgae either for nutraceutical, food or for energy applications. This study is particularly focused on the influence of the pretreatments upon extraction kinetics and yields. This study proposes a complete study at laboratory scale (10 g per batch of dry biomass) of the influence of pretreatments (type of drying and grinding) and of water content on the extraction kinetics and yields as well as on the oil composition in terms of lipidic classes and profiles. Two drying pretreatments (drying under air flow and freeze-drying) applied on Nannochloropsis oculata were studied. Extraction experiments were carried out at 40 MPa, 333 K, with a carbon dioxide flow rate of 0.5 kg h−1 and for different granulometries. Results showed that drying under air flow at 308 K is the most adequate pretreatment leading to the most rapid kinetics. Whatever the pretreatment used, the extracted oil contains more than 90 wt% of triglycerides and does not contain phospholipids. As expected, the smaller the particle size, the faster the extraction kinetics. Finally, an increase in the biomass water content up to 20 wt% increases the global extraction kinetics (extraction of both water and oil) but appears to have no influence on oil extraction yields. Moreover, the extraction of neutral lipids happens to be complete for a CO2/charge mass ratio ranging from 30 to 130 depending on the operating conditions and on the characteristics of the treated biomass. Finally, pilot scale experiments were performed with batches up to 15 kg in order to evaluate the influence of pressure and particle size on the extraction kinetics and yields. Extracts obtained at 333 K with operating pressures of 50 MPa and 85 MPa have similar compositions and do not contain phospholipids.
Christelle Crampon, Adil Mouahid, Sid-Ali Amine Toudji, Olivier Lépine, Elisabeth Badens. Influence of pretreatment on supercritical CO2 extraction from Nannochloropsis oculata. Journal of Supercritical Fluids, Elsevier, 2013, 79, pp.337-344. ⟨10.1016/j.supflu.2012.12.022⟩. ⟨hal-00993082⟩
Adil Mouahid, Christelle Crampon, Sid-Ali Amine Toudji, Elisabeth Badens. Supercritical CO2 extraction of neutral lipids from microalgae: experiments and modelling. Journal of Supercritical Fluids, Elsevier, 2013, 77, pp.7-16. ⟨10.1016/j.supflu.2013.01.024⟩. ⟨hal-00993077⟩ Plus de détails...
The aim of this work is to show that the equations developed by Sovová, based on the concept of broken and intact cells for describing the supercritical extraction curves from plants and vegetables, can be applied for the modelling of the supercritical CO2 extraction curves obtained with microalgae. Experimental and modelling results of supercritical carbon dioxide extraction of lipids from four different microalgae: Nannochloropsis oculata, Cylindrotheca closterium, Chlorella vulgaris and Spirulina platensis, are presented. The experimental setup is a laboratory scale apparatus which allows an accurate monitoring of the mass loss of the microalgae sample during the extraction. The experimental data were obtained at a pressure of 40 MPa, a temperature of 333 K and CO2 flow rates from 0.3 to 0.5 kg/h. The extraction experiments were performed on samples having undergone different pretreatments: (i) after harvesting and centrifugation, microalgae were dried either by freeze-drying or air flow drying) and (ii) they were ground and sieved at different particle sizes (particle diameters ranging from 160 to 1000 μm). The complete extraction of neutral lipids was performed leading to mass losses up to 30% depending on the samples and on the operating conditions. Extracts were mainly composed of triglycerides (more than 90 wt% of extracts). The mathematical model published in 2005 and the simplified equations of extraction curves (using the characteristic times characterizing each extraction step) published in 2012 by Sovová were chosen to fit the experimental data. Among the hypotheses proposed by Sovovà, we considered that the flow pattern of supercritical CO2 in the extraction autoclave was plug flow and the extraction process was supposed to occur with negligible solute-matrix interactions. The adjustable parameters were calculated by minimizing the sum of least squares between experimental and calculated values of the extraction yield. Good agreement between the two models and our experimental measurements was obtained. The average absolute relative deviation ranges between 0.5 and 10.2%.
Adil Mouahid, Christelle Crampon, Sid-Ali Amine Toudji, Elisabeth Badens. Supercritical CO2 extraction of neutral lipids from microalgae: experiments and modelling. Journal of Supercritical Fluids, Elsevier, 2013, 77, pp.7-16. ⟨10.1016/j.supflu.2013.01.024⟩. ⟨hal-00993077⟩
Adil Mouahid, David Bessieres, Frédéric Plantier, Gilles Pijaudier-Cabot. Supercritical adsorption of nitrogen on EcoSorb-activated carbon at temperatures up to 383 K and pressures up to 2 MPa. Journal of Thermal Analysis and Calorimetry, Springer Verlag, 2012, 102 (1), pp.473-479. ⟨10.1007/s10973-011-1762-8⟩. ⟨hal-00710850⟩ Plus de détails...
Single adsorption isotherms and differential enthalpies of adsorption of nitrogen were measured on a microporous-activated carbon at various temperatures. A new way for calculating the differential enthalpies of adsorption is presented, and the results obtained were compared to those obtained by the isosteric method derived from the equilibrium data using the Clausius-Clapeyron equation. The measurements were made thanks to a coupled thermostated calorimetric-manometric apparatus which can be operated for pressures up to 2.5 MPa and temperatures from 303 to 423 K. This article provides experimental data which can be used for the adjustment of interaction potential in computational simulations for supercritical adsorption.
Adil Mouahid, David Bessieres, Frédéric Plantier, Gilles Pijaudier-Cabot. Supercritical adsorption of nitrogen on EcoSorb-activated carbon at temperatures up to 383 K and pressures up to 2 MPa. Journal of Thermal Analysis and Calorimetry, Springer Verlag, 2012, 102 (1), pp.473-479. ⟨10.1007/s10973-011-1762-8⟩. ⟨hal-00710850⟩
Journal: Journal of Thermal Analysis and Calorimetry
