Elaboration en milieu supercritique d’implants intravitréens à libération prolongée d’inhibiteurs de facteurs de croissance endothéliaux (anti-VEGF) / (thèse 2020 - 2023)
Activités
Implants intravitréens,
Systèmes à libération contrôlée,
Anticorps,
Encapsulation supercritique,
PGSS,
Dispositifs médicaux.
Publications scientifiques au M2P2
2024
M. Schneider, Y. Masmoudi, C. Girard, F. Matonti, C. Olmière, et al.. Sequential-Dispersion PGSS process applied to lutein encapsulation at moderate temperatures: A solvent-free method for thermosensitive compound encapsulation. Journal of Supercritical Fluids, 2024, 207, pp.106186. ⟨10.1016/j.supflu.2024.106186⟩. ⟨hal-05042395⟩ Plus de détails...
Sequential-dispersion PGSS (SD-PGSS) applied to polymer excipient processing.
• Solvent-free SD-PGSS applied to the elaboration of controlled release drug delivery systems. • Lutein encapsulation with biocompatible polymers for oral uptake in AMD mitigation. • Process yields up to 94% under moderate temperatures (38 and 45 • C). • Modulation of lutein release profile from solid formulation.
M. Schneider, Y. Masmoudi, C. Girard, F. Matonti, C. Olmière, et al.. Sequential-Dispersion PGSS process applied to lutein encapsulation at moderate temperatures: A solvent-free method for thermosensitive compound encapsulation. Journal of Supercritical Fluids, 2024, 207, pp.106186. ⟨10.1016/j.supflu.2024.106186⟩. ⟨hal-05042395⟩
